The vertebrate Hox gene regulatory network for hindbrain segmentation: Evolution and diversification: Coupling of a Hox gene regulatory network to hindbrain segmentation is an ancient trait originating at the base of vertebrates. (29th March 2016)

• Record Type: Journal Article
• Authors: Parker, Hugo J.; Bronner, Marianne E.; Krumlauf, Robb
• Is Part Of: BioEssays. Volume 38:Number 6(2016:Jun.)
• Page Start: 526
• Page End: 538
• Publication Date: 2016-03-29
• Subjects: chordates -- gene regulatory networks -- hindbrain -- Hox genes -- rhombomeres -- segmentation -- vertebrate evolution; Molecular biology -- Periodicals; Cytology -- Periodicals; Developmental biology -- Periodicals; 572.8
• DOI: 10.1002/bies.201600010
• Languages: English
• ISSNs: 0265-9247

Abstract

Abstract : Hindbrain development is orchestrated by a vertebrate gene regulatory network that generates segmental patterning along the anterior–posterior axis via Hox genes. Here, we review analyses of vertebrate and invertebrate chordate models that inform upon the evolutionary origin and diversification of this network. Evidence from the sea lamprey reveals that the hindbrain regulatory network generates rhombomeric compartments with segmental Hox expression and an underlying Hox code. We infer that this basal feature was present in ancestral vertebrates and, as an evolutionarily constrained developmental state, is fundamentally important for patterning of the vertebrate hindbrain across diverse lineages. Despite the common ground plan, vertebrates exhibit neuroanatomical diversity in lineage‐specific patterns, with different vertebrates revealing variations of Hox expression in the hindbrain that could underlie this diversification. Invertebrate chordates lack hindbrain segmentation but exhibit some conserved aspects of this network, with retinoic acid signaling playing a role in establishing nested domains of Hox expression. Abstract : A developmental gene regulatory network couples Hox gene expression to hindbrain segmentation in all vertebrates. Evidence from jawless vertebrates and invertebrate chordates indicates that this pan‐vertebrate network originated from an ancient anterior–posterior patterning program. Cross‐species comparisons suggest diversification in the network may contribute to neuro‐anatomical differences between vertebrates.