A copper-catalyzed aerobic domino process for the synthesis of isoindolin-1-ylidene derivatives. Issue 22 (3rd June 2015)
- Record Type:
- Journal Article
- Title:
- A copper-catalyzed aerobic domino process for the synthesis of isoindolin-1-ylidene derivatives. Issue 22 (3rd June 2015)
- Main Title:
- A copper-catalyzed aerobic domino process for the synthesis of isoindolin-1-ylidene derivatives
- Authors:
- Chen, Hu
Wang, Qian
Huang, Yong - Abstract:
- Abstract: A convenient and efficient copper-catalyzed aerobic cascade reaction has been developed for the synthesis of the pharmacologically relevant isoindolin-1-ylidene scaffold. We discovered that various ortho -formyl cinnamates could react smoothly with different amines in the presence of a commercially available copper catalyst under mild aerobic conditions. Isoindolin-1-ylidene derivatives were assembled in one pot in moderate to good yields. This method features amine annulation and double dehydrogenation, representing high atomic efficiency. Its product could be further converted to the privileged isoindolinone pharmacophore. Graphical abstract:
- Is Part Of:
- Tetrahedron. Volume 71:Issue 22(2015)
- Journal:
- Tetrahedron
- Issue:
- Volume 71:Issue 22(2015)
- Issue Display:
- Volume 71, Issue 22 (2015)
- Year:
- 2015
- Volume:
- 71
- Issue:
- 22
- Issue Sort Value:
- 2015-0071-0022-0000
- Page Start:
- 3632
- Page End:
- 3636
- Publication Date:
- 2015-06-03
- Subjects:
- Isoindolinone -- Dehydrgenation -- Aerobic -- Copper -- Cascade
Chemistry, Organic -- Periodicals
547.005 - Journal URLs:
- http://www.elsevier.com/journals ↗
- DOI:
- 10.1016/j.tet.2014.11.071 ↗
- Languages:
- English
- ISSNs:
- 0040-4020
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8796.850000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 1011.xml