A facile and highly convergent approach to thiazolo[3, 2-a]pyridines via one-pot multicomponent domino reaction under metal-free and solvent-free conditions. Issue 21 (27th May 2015)

• Record Type: Journal Article
• Authors: Nagaraju, Anugula; Janaki Ramulu, B.; Shukla, Gaurav; Srivastava, Abhijeet; Verma, Girijesh Kumar; Raghuvanshi, Keshav; Singh, Maya Shankar
• Is Part Of: Tetrahedron. Volume 71:Issue 21(2015)
• Page Start: 3422
• Page End: 3427
• Publication Date: 2015-05-27
• Subjects: Thiazolopyridinones -- α-Enolic dithioesters -- One-pot domino reactions -- Solvent-free conditions -- Metal-free -- P2O5; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2015.03.087
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Operationally and user-simple a highly efficient one-pot three-component (5 molecules) coupling of α-enolic dithioesters, cysteamine hydrochloride and aldehydes afforded a range of thiazolopyridines in high yields under metal-free and solvent-free conditions. The new domino protocol generated two rings by the concomitant formation of seven multiple bonds (two C–C, three C–N and two C–S) involving a sequence of N, S -acetal formation/double Michael addition/N-cyclization as key steps in a single operation. Graphical abstract: