Expression and secretion pattern of FljB of Salmonella enterica serovar Typhi in different culture conditions. (June 2016)

• Record Type: Journal Article
• Authors: Zheng, Xueming; Zhang, Qisi; Ji, Ying; Zhao, Xin; Ni, Bin; Xu, Shungao; Huang, Xinxiang
• Is Part Of: Microbial pathogenesis. Volume 95(2016)
• Page Start: 142
• Page End: 147
• Publication Date: 2016-06
• Subjects: Salmonella enterica serovar Typhi -- FljB -- SPI-1 inducing condition -- SPI-2 inducing condition -- Secretion; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2016.04.004
• Languages: English
• ISSNs: 0882-4010

Abstract

Highlights: Flagellin of Salmonella is highly immunogenic and is a key protein recognized by the host immune system. SPI-1 inducing condition increases the secretion but not the expression level of FljB. SPI-2 inducing condition shut down the expression and consequential secretion of FljB. Salmonella may subvert the host's innate immune system through regulation of the expression and secretion of Flagellin.