2D wax-printed paper substrates with extended solvent supply capabilities allow enhanced ion signal in paper spray ionization. Issue 12 (28th April 2016)

• Record Type: Journal Article
• Authors: Damon, Deidre E.; Maher, Yosef S.; Yin, Mengzhen; Jjunju, Fred P. M.; Young, Iain S.; Taylor, Stephen; Maher, Simon; Badu-Tawiah, Abraham K.
• Is Part Of: Analyst. Volume 141:Issue 12(2016)
• Page Start: 3866
• Page End: 3873
• Publication Date: 2016-04-28
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/c6an00168h
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : Paper-based microfluidic channels were created from solid wax printing, and the resultant 2D wax-printed paper substrates were used for paper spray (PS) mass spectrometry (MS) analysis of small organic compounds. Abstract : Paper-based microfluidic channels were created from solid wax printing, and the resultant 2D wax-printed paper substrates were used for paper spray (PS) mass spectrometry (MS) analysis of small organic compounds. Controlling fluid flow at the tip of the wax-printed paper triangles enabled the use of lower spray voltages (0.5–1 kV) and extended signal lifetime (10 minutes) in PS-MS. High sensitivity (sub ng mL −1 levels) and quantitation precision (<10% RSD) have been achieved in the analysis of illicit drugs in 4 μL of raw urine (fresh and dry), as well as corrosion inhibitors and pesticides in water samples. The reported study encourages the future development of disposable 3D microfluidic paper-based analytical devices, which function with simple operation but capable of on-chip analyte detection by MS; such a device can replace the traditional complex laboratory procedures for MS analysis to enable on-site in situ sampling with portable mass spectrometers.