Reduced serologic sensitivity to influenza A virus illness among inactivated influenza vaccinees. Issue 30 (24th June 2016)

• Record Type: Journal Article
• Authors: Thompson, Mark G.; Gaglani, Manjusha J.; Naleway, Allison L.; Dowell, Samuel H.; Spencer, Sarah; Ball, Sarah; Levine, Min; Fry, Alicia
• Is Part Of: Vaccine. Volume 34:Issue 30(2016)
• Page Start: 3443
• Page End: 3446
• Publication Date: 2016-06-24
• Subjects: Influenza -- Hemagglutinin inhibition -- Seroconversion -- Antibody -- Influenza vaccine -- Immunogenicity -- Vaccine failure; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2016.04.085
• Languages: English
• ISSNs: 0264-410X

Abstract

Abstract: We compared ≥4-fold increases in antibody titers by hemagglutination inhibition assay to RT-PCR results among 42 adults with PCR-confirmed influenza A virus illnesses. Serologic sensitivity was higher among unvaccinated (69%, 95% confidence interval [CI] = 48–90%) than vaccinated healthcare personnel (38%, 95% CI = 29–46%) in a 2010–11 prospective cohort.