Levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis. (July 2016)

• Record Type: Journal Article
• Authors: Tekeoğlu, İbrahim; Harman, Halil; Sağ, Sinem; Altındiş, Mustafa; Kamanlı, Ayhan; Nas, Kemal
• Is Part Of: Cytokine. Volume 83(2016)
• Page Start: 171
• Page End: 175
• Publication Date: 2016-07
• Subjects: Inflammatory markers -- Pentraxin 3 -- Rheumatoid arthritis; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2016.04.009
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlight: Elevated levels of pentraxin-3, fetuin-A might play a role in the pathogenesis of RA. Pentraxin-3 and fetuin-A are new biomarkers. They should provide important contributions to optimize medical treatment and recruit clinical outcomes in patients with RA. Abstract: Objective: The aim of this study was to investigate the relationship between disease severity and biochemical parameters such as pentraxin-3, fetuin-A, IL-6, insulin and HOMA-IR levels in patients with rheumatoid arthritis. Methods: This study included 60 patients with RA and 20 healthy controls. Serum pentraxin-3, fetuin-A, IL-6 and insulin concentrations were measured. Also, HOMA-IR values were calculated. Disease activity was assessed with Disease Activity Score (DAS28). To evaluate quality of life, the Health Assessment Questionnaire disability index was applied. Results: The serum values for ESR, CRP, pentraxin-3 and fetuin-A in patients with RA were found to be higher than control subjects (p values = 0.001, 0.001, 0.000, 0.000, 0.01, 0.02, respectively). A positive correlation was evident between the DAS 28 score and IL6 levels (r = 0.263, p = 0.045). We found no correlation between the DAS28 score and HOMA-IR, the levels of pentraxin 3, fetuin A, insulin (p < 0.05). Fetuin A levels were positively correlated with cumulative steroid dose (r = 0.382, p = 0.035). A statistically significant correlation was evident between presence of cardiovascular disease and HOMA-IR values in RA patients (r = 0.437, p = 0.032). Conclusion: Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of RA. Levels of fetuin-A, insulin HOMA-IR, pentraxin-3, CRP and ESR were not associated with clinical severity of the RA.