Synthesis, antimycobacterial evaluation and pharmacophore modeling of analogues of the natural product formononetin. Issue 12 (15th June 2015)

• Record Type: Journal Article
• Authors: Mutai, Peggoty; Pavadai, Elumalai; Wiid, Ian; Ngwane, Andile; Baker, Bienyameen; Chibale, Kelly
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 12(2015)
• Page Start: 2510
• Page End: 2513
• Publication Date: 2015-06-15
• Subjects: Antimycobacterial -- Formononetin -- Pharmacophore -- Structure -- Activity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.04.064
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: The synthesis and antimycobacterial activity of formononetin analogues is hereby reported. Formononetin and its analogue11E showed 88% and 95% growth inhibition, respectively, against the H37Rv strain of Mycobacterium tuberculosis. Pharmacophore modeling studies indicated that the presence of a hydroxyl group in formononetin and its analogues, is crucial for maintaining activity.