A fluorescent bisboronic acid compound that selectively labels cells expressing oligosaccharide Lewis X. Issue 12 (15th June 2015)

• Record Type: Journal Article
• Authors: Gao, Xingming; Zhu, Mengyuan; Fan, Haiying; Yang, Wenqian; Ni, Weijuan; Karnati, Vishnu V.R.; Gao, Shouhai; Carson, John; Weston, Brent; Wang, Binghe
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 12(2015)
• Page Start: 2501
• Page End: 2504
• Publication Date: 2015-06-15
• Subjects: Biomarker -- Boronolectin -- Optical imaging; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.04.069
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: Two fluorescent diboronic acid compounds (6a and6b ) with a dipeptide linker were synthesized as potential sensors for cell surface saccharide Lewis X (Le X ). Compound6a with a dipeptide (H-Asp-Ala-) as the linker was found to selectively label CHOFUT4 cells, which express Le x, at micromolar concentrations, while non-Le x -expressing control cells were not labeled.