Activity of lipo-cyclic γ-AApeptides against biofilms of Staphylococcus epidermidis and Pseudomonas aeruginosa. Issue 12 (15th June 2015)

• Record Type: Journal Article
• Authors: Padhee, Shruti; Li, Yaqiong; Cai, Jianfeng
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 12(2015)
• Page Start: 2565
• Page End: 2569
• Publication Date: 2015-06-15
• Subjects: Biofilm prevention -- Peptidomimetics -- Antimicrobial; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.04.039
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Lipo-cyclic γ-AApeptides effectively prevent biofilm formation and reduce biomass. Abstract: Antibiotic resistant bacterial infection is currently a serious public concern. Their ability to form biofilms further complicates the treatment. Herein we investigated the activity of lipo-cyclic γ-AApeptides against both planktonic cells and biofilms of Staphylococcus epidermidis and Pseudomonas aeruginosa, in comparison to those of the conventional antibiotic ciprofloxacin. Our results suggest that these lipo-cyclic γ-AApeptides exhibit comparable or enhanced performance compared to ciprofloxacin in the prevention of biofilm formation for both Gram-positive and Gram-negative bacteria, providing a potential alternative treatment and prevention for indwelling device-related infections.