Borderline ankle-brachial index is associated with poor short-term clinical outcome after coronary artery intervention. (June 2016)

• Record Type: Journal Article
• Authors: Lee, Seung Hwa; Choi, Seung-Hyuk; Kim, Eun Kyoung; Yang, Jeong Hoon; Song, Young Bin; Hahn, Joo-Yong; Choi, Jin-Ho; Gwon, Hyeon-Cheol; Lee, Sang Hoon; Kim, Duk-Kyung
• Is Part Of: Atherosclerosis. Volume 249(2016)
• Page Start: 186
• Page End: 190
• Publication Date: 2016-06
• Subjects: Coronary artery disease -- Borderline ankle-brachial index -- Percutaneous coronary intervention; PAD peripheral artery disease -- CAD coronary artery disease -- PCI percutaneous coronary intervention -- ABI ankle-brachial index -- MI myocardial infarction -- MACCE major adverse cardiac and cerebrovascular event; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2016.03.027
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Objective: To evaluate the association between borderline ankle-brachial index (ABI) and clinical outcome in patients who underwent percutaneous coronary intervention (PCI). Methods: From August 2009 to August 2012, ABI was measured in 1291 patients who underwent PCI. Patients with borderline ABI were compared with those who had normal ABI. The primary outcome was major adverse cardiac and cerebrovascular event (MACCE), defined as a composite of all-cause death, myocardial infarction, stroke, and repeat revascularization. Results: Of the 1291 patients, 1154 (82%) had normal ABI and 89 (7%) had borderline ABI. The median overall follow-up duration was 19 (interquartile range 13–26) months. After adjustment with IPTW, the incidence of stroke (HR, 6.28; CI 95%, 1.95–20.19; P < 0.01) and MACCE (HR, 2.54; CI 95%, 1.40–4.62; P < 0.01) were higher in the borderline ABI group. In a propensity score-matched population, the incidence of stroke (HR, 4.68; CI 95%, 1.18–18.52; p = 0.03) and MACCE (HR, 2.12; CI 95%, 1.09–4.11; P = 0.03) were still significantly higher. Conclusion: The presence of borderline ABI was associated with worse clinical outcome and increased stroke rate compared with normal ABI during the short-term follow-up period in patients who underwent coronary intervention. Highlights: Among patients underwent PCI, the borderline ABI was associated with stroke in short-term follow-up period. The borderline ABI was associated with worse clinical outcomes including higher stroke rate in patients underwent PCI. We undergo propensity-score matching and inverse probability of treatment weighted analysis to retain a large sample size and maximize the study power while maintaining a balance in covariates between the two groups.