A randomized controlled trial of the effects of vitamin D supplementation on arterial stiffness and aortic blood pressure in Native American women. Issue 2 (June 2015)

• Record Type: Journal Article
• Authors: Gepner, Adam D.; Haller, Irina V.; Krueger, Diane C.; Korcarz, Claudia E.; Binkley, Neil; Stein, James H.
• Is Part Of: Atherosclerosis. Volume 240:Issue 2(2015)
• Page Start: 526
• Page End: 528
• Publication Date: 2015-06
• Subjects: Arterial stiffness -- Vitamin D -- Central blood pressure -- Cardiovascular disease risk; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.04.795
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Objective: It is unclear if vitamin D supplementation improves central blood pressure or arterial stiffness in Native American (NA) women. Methods: Healthy postmenopausal NA women were randomized to receive 400 IU or 2500 IU of vitamin D for 6 months. Central systolic blood pressure (cSBP), central pulse pressure (cPP) and aortic augmentation index (AIx) were estimated by tonometry at baseline and after 6 months. Results: Study volunteers (n = 98) were 61 (7.3) years old. 25(OH)D was 26.4 (11.0) ng/mL. 25(OH)D was similar between the two treatment groups (p = 0.291), as were baseline cSBP, cPP, and CVD risk factors (all p > 0.1). Treatment with 2500 IU of daily vitamin D3 did not affect cSBP, cPP, or AIx (all p > 0.1) compared to 400 IU daily. Conclusions: Despite low serum 25(OH)D at baseline, 6 months of vitamin D supplementation did not improve central blood pressure parameters or arterial stiffness in NA women. Clinical trials. gov identifier: NCT01490333 .