A catalyst-free, one-pot multicomponent synthesis of spiro-benzimidazoquinazolinones via a Knoevenagel–Michael-imine pathway: a microwave assisted approach. Issue 48 (27th April 2016)

• Record Type: Journal Article
• Authors: Maloo, Preeti; Roy, Tapta Kanchan; Sawant, Devesh M.; Pardasani, Ram T.; Salunkhe, Manikrao M.
• Is Part Of: RSC advances. Volume 6:Issue 48(2016)
• Page Start: 41897
• Page End: 41906
• Publication Date: 2016-04-27
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra05322j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A multi-component route for the synthesis of spiro-benzimidazoquinazolinones was developed and its mechanism was studied. Abstract : A novel multi-component route for the synthesis of spiro-benzimidazoquinazolinones has been developed under microwave irradiation. It involves a one-pot three-component reaction of acenaphthoquinone or isatin, 1, 3-diketone and 2-aminobenzimidazole in ethanol at 180 W and 160 °C temperature. An attractive feature of this method is the mild conditions with operational simplicity. The computational studies provide insight into the mechanistic aspects of the reaction.