Copper-catalyzed aerobic oxidative decarboxylative amination of arylacetic acids: a facile access to 2-arylquinazolines. Issue 42 (13th April 2016)

• Record Type: Journal Article
• Authors: Yan, Yizhe; Shi, Miaomiao; Niu, Bin; Meng, Xiangping; Zhu, Changrui; Liu, Gengyao; Chen, Ting; Liu, Yanqi
• Is Part Of: RSC advances. Volume 6:Issue 42(2016)
• Page Start: 36192
• Page End: 36197
• Publication Date: 2016-04-13
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra04195g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : An efficient copper-catalyzed oxidative decarboxylative amination of arylacetic acids with 2-aminobenzoketones and ammonium acetate under an oxygen atmosphere was first developed. Abstract : An efficient copper-catalyzed oxidative decarboxylative amination of arylacetic acids with 2-aminobenzoketones and ammonium acetate under an oxygen atmosphere was first developed. This reaction represents a novel avenue for 2-arylquinazolines in good to excellent yields via multiple C–N bond formations. This protocol features inexpensive copper as the catalyst, molecular oxygen as the sole oxidant, H2 O and CO2 as wastes, and a broad substrate scope.