Antitumor activity of Dendrobium devonianum polysaccharides based on their immunomodulatory effects in S180 tumor-bearing mice. Issue 46 (22nd April 2016)

• Record Type: Journal Article
• Authors: Tong, Litao; Wang, Lili; Zhou, Xianrong; Zhong, Kui; Liu, Liya; Wang, Fengzhong; Zhou, Sumei
• Is Part Of: RSC advances. Volume 6:Issue 46(2016)
• Page Start: 40250
• Page End: 40257
• Publication Date: 2016-04-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra03074b
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The aim of the present study is to investigate the antitumor activity and immunostimulatory effect of the water-soluble polysaccharides (DDP) from stem of Dendrobium devonianum in S180 tumor-bearing mice. Abstract : The aim of the present study is to investigate the antitumor activity and immunostimulatory effect of the water-soluble polysaccharides (DDP) from stem of Dendrobium devonianum in S180 tumor-bearing mice. The mice were divided into 3 groups, and then DDP or Ganoderma lucidum polysaccharides (GLP) dissolved in deionized water were given to the mice at a dose of 200 mg kg −1 for 30 days. DDP, as well as GLP, significantly inhibited the growth of mouse transplantable tumors and promoted spleen indexes, delayed-type hypersensitivity reaction, natural killer cell activity, macrophage phagocytosis and lymphocyte proliferation. Moreover, DDP and GLP increased the colonic acetate, butyrate and total short-chain fatty acid (SCFA) concentrations. These results indicated that oral administration of DDP significantly inhibited the growth of transplanted tumors in S180 tumor-bearing mice by improving specific and non-specific immune responses, as well as increasing colonic SCFAs.