Formation of calcium phosphate nanostructures under the influence of self-assembling hybrid elastin-like-statherin recombinamers. Issue 37 (29th March 2016)

• Record Type: Journal Article
• Authors: Misbah, M. Hamed; Espanol, M.; Quintanilla, Luis; Ginebra, M. P.; Rodríguez-Cabello, J. Carlos
• Is Part Of: RSC advances. Volume 6:Issue 37(2016)
• Page Start: 31225
• Page End: 31234
• Publication Date: 2016-03-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra01100d
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The self-assembly properties of elastin-like-statherin recombinamers have great influence on calcium phosphate mineralization. Abstract : The self-assembling properties of thermally-sensitive amphiphilic elastin-like multiblock recombinamers have been combined with the capacities of calcium phosphate binding of the SNA 15 epitope inspired by the salivary protein statherin. In this regard, the interaction between calcium and phosphate ions was examined in the presence of two hybrid recombinamers. The first recombinamer comprised a simple amphiphilic diblock in which the SNA 15 epitopes were combined, at the gene level, to the hydrophilic end. This recombinamer can self-assemble into nanoparticles that can control the transformation of amorphous calcium phosphate (ACP) into a fibre-like hydroxyapatite structure. In the other recombinamer, the SNA 15 domains are distributed along the monomer chain, with the hydrophilic blocks being distributed amongst the hydrophobic ones. In this case, the resulting nanohybrid ACP/recombinamer organises into neuron-like structures. Thus, combining the amphiphilic elastin-like recombinamers to the SNA 15 functionality is a powerful mean to tune the formation of different complex calcium phosphate nanostructures.