Palladium-catalyzed ortho-acylation of N-Nitrosoanilines with α-oxocarboxylic acids: a convenient method to synthesize N-Nitroso ketones and indazoles. Issue 23 (8th June 2016)

• Record Type: Journal Article
• Authors: Zhang, Liang; Wang, Zhe; Guo, Peiyu; Sun, Wei; Li, Ya-Min; Sun, Meng; Hua, Chengwen
• Is Part Of: Tetrahedron letters. Volume 57:Issue 23(2016)
• Page Start: 2511
• Page End: 2514
• Publication Date: 2016-06-08
• Subjects: Palladium-catalyzed -- Acylation -- CH bond cleavage -- N-nitroso ketones -- Indazoles; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.04.096
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: An efficient and mild protocol for regioselective synthesis of N-Nitroso aryl ketones is described. This chemistry offered a convenient access to a range of indazoles. Palladium-catalyzed decarboxylative ortho -acylation of CH bond is very important. Abstract: An efficient and mild protocol for regioselective synthesis of N-Nitroso aryl ketones by palladium-catalyzed direct acylation of arenes using N-Nitroso as directing groups is described. This reaction proceeded smoothly and could tolerate a variety of functional groups. Moreover, this chemistry offers a convenient access to a range of indazoles.