A series of diphenylamine-fluorenone derivatives as potential fluorescent probes for neuroblastoma cell staining. Issue 22 (2nd June 2016)

• Record Type: Journal Article
• Authors: Capodilupo, Agostina-Lina; Vergaro, Viviana; Accorsi, Gianluca; Fabiano, Eduardo; Baldassarre, Francesca; Corrente, Giuseppina Anna; Gigli, Giuseppe; Ciccarella, Giuseppe
• Is Part Of: Tetrahedron. Volume 72:Issue 22(2016)
• Page Start: 2920
• Page End: 2928
• Publication Date: 2016-06-02
• Subjects: Fluorescent dyes -- Fluorenone-derivatives -- Neuroblastoma -- Bioimaging; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2016.04.012
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A new series of D–π–A (TKB1 -TKB3 ) structural chromophores with various electron donor units were designed, synthesized, and fully characterized. Their photophysical properties and cytotoxicity were investigated, and practical applications evaluated by fluorescence imaging in living cells. A direct dependence of the optical properties on the electron donor groups has been revealed for all the samples. To this purpose, time-dependent density functional theory calculations were conducted. Finally, dyes showed high biocompatibility, long-term retention and low cytotoxicity in different cell-lines including neuroblastoma cell (SH-SY5). Graphical abstract: