Eight linear peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020. Issue 22 (2nd June 2016)

• Record Type: Journal Article
• Authors: Liang, Xiao; Zhang, Xiao-Yong; Nong, Xu-Hua; Wang, Jie; Huang, Zhong-Hui; Qi, Shu-Hua
• Is Part Of: Tetrahedron. Volume 72:Issue 22(2016)
• Page Start: 3092
• Page End: 3097
• Publication Date: 2016-06-02
• Subjects: Deep-sea-derived fungus -- Simplicillium obclavatum -- Linear peptide -- Antifouling -- Cytotoxicity; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2016.04.032
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Eight new linear peptides, simplicilliumtides A–H (1 –8 ) were isolated from a culture broth of the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were determined by Marfey's method. Compounds1 –2 are linear tetrapeptides possessing a 2-aminobenzoic acid residue. Compounds3 –8 are acetylated linear tri- or di-peptides. Their antifouling, antibacterial, cytotoxic, and acetylcholinesterase inhibiting activities were evaluated. Compound4 showed strong antifouling activity against Bugula neritina larvae settlement. And1, 5, 7 and8 showed weak cytotoxicity towards human leukemia HL-60 or K562 cell line. Graphical abstract: