The activity in the anterior insulae is modulated by perceptual decision-making difficulty. (7th July 2016)

• Record Type: Journal Article
• Authors: Lamichhane, Bidhan; Adhikari, Bhim M.; Dhamala, Mukesh
• Is Part Of: Neuroscience. Volume 327(2016)
• Page Start: 79
• Page End: 94
• Publication Date: 2016-07-07
• Subjects: BOLD blood oxygen level dependent -- C color coherence -- dACC dorsal anterior cingulate cortex -- fMRI functional magnetic resonance imaging -- GLM general linear model -- IC color incoherence -- INSs anterior insulae -- MNI Montreal Neurological Institute -- PDM perceptual decision-making -- RDM random dots motion -- RT response time -- TR repetition time; functional magnetic resonance imaging -- task difficulty -- response time -- salience network; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.04.016
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: This study includes four perceptual decision-making experiments. We measured fMRI BOLD activity changes using visual and audio-visual stimuli. Decision response times increased with the ambiguity of presented stimuli. Bilateral insulae were activated with a varying degree of degraded sensory inputs. The activities on bilateral insulae consistently increased with task difficulty. Abstract: Previous neuroimaging studies provide evidence for the involvement of the anterior insulae (INSs) in perceptual decision-making processes. However, how the insular cortex is involved in integration of degraded sensory information to create a conscious percept of environment and to drive our behaviors still remains a mystery. In this study, using functional magnetic resonance imaging (fMRI) and four different perceptual categorization tasks in visual and audio-visual domains, we measured blood oxygen level dependent (BOLD) signals and examined the roles of INSs in easy and difficult perceptual decision-making. We created a varying degree of degraded stimuli by manipulating the task-specific stimuli in these four experiments to examine the effects of task difficulty on insular cortex response. We hypothesized that significantly higher BOLD response would be associated with the ambiguity of the sensory information and decision-making difficulty. In all of our experimental tasks, we found the INS activity consistently increased with task difficulty and participants' behavioral performance changed with the ambiguity of the presented sensory information. These findings support the hypothesis that the anterior insulae are involved in sensory-guided, goal-directed behaviors and their activities can predict perceptual load and task difficulty.