Preterm labor and neonatal sepsis caused by intrauterine Helicobacter cinaedi infection. Issue 6 (June 2016)

• Record Type: Journal Article
• Authors: Maki, Yohei; Furukawa, Seishi; Kodama, Yuki; Sumiyoshi, Kaeko; Kino, Emi; Sameshima, Hiroshi
• Is Part Of: Journal of infection and chemotherapy. Volume 22:Issue 6(2016:Jun.)
• Page Start: 414
• Page End: 416
• Publication Date: 2016-06
• Subjects: Helicobacter cinaedi -- Intrauterine infection -- Neonatal sepsis; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2015.12.008
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: Helicobacter cinaedi is a rare pathogen but known to cause bacteremia, cellulitis and enterocolitis. Recently, cases of involving various organs are increasingly reported such as endocarditis, meningitis, and kidney cyst infection. We report a case of intrauterine H . cinaedi infection leading preterm birth and neonatal sepsis. A 29-year-old pregnant women who was no underlying disease hospitalized due to threatened preterm labor at 22 weeks of gestation. Clinical findings showed uterine tenderness, fever, leukocytosis and elevated C-reactive protein. H . cinaedi was isolated from amniotic fluid obtained by transabdominal amniocentesis. We diagnosed as intrauterine H . cinaedi infection and administered intravenous ampicillin followed by oxytocin to terminate pregnancy. A live 446 g male infant was delivered. The patient was no signs of infection throughout postpartum course and discharged on post-delivery day 5. The neonate was admitted in neonatal intensive care unit and administered ampicillin and amikacin. H . cinaedi was isolated from umbilical cord blood culture. He has no signs of infection on day 5 but died from uncontrollable hyperglycemia and ketoacidosis on 15 days of age. H . cinaedi can cause intrauterine infection during pregnancy and lead preterm labor and neonatal sepsis.