Antioxidant activity and photostability of α-tocopherol/β-cyclodextrin inclusion complex encapsulated electrospun polycaprolactone nanofibers. (June 2016)

• Record Type: Journal Article
• Authors: Aytac, Zeynep; Uyar, Tamer
• Is Part Of: European polymer journal. Volume 79(2016:Jun.)
• Page Start: 140
• Page End: 149
• Publication Date: 2016-06
• Subjects: α-Tocopherol -- β-Cyclodextrin -- Polycaprolactone -- Nanofiber -- Antioxidant activity -- Photostability; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2016.04.029
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: PCL NF encapsulating α-TC and α-TC/β-CD-IC was produced by electrospinning. AO activity of PCL/α-TC/β-CD-IC-NF was higher than PCL/α-TC-NF in methanol:water. AO activity of released α-TC was higher from PCL/α-TC/β-CD-IC-NF than PCL/α-TC-NF. PCL/α-TC/β-CD-IC-NF protected α-TC from UV-light more efficiently than PCL/α-TC-NF. Abstract: Cyclodextrin inclusion complexes (CD-ICs) can be encapsulated into electrospun nanofibers in order to achieve delivery systems having high surface area and highly porous nanofibrous structures. In this study, a well-known antioxidant molecule, α-tocopherol (α-TC) (vitamin E) was chosen as an active agent for inclusion complexation with β-cyclodextrin. Polycaprolactone (PCL) nanofibers encapsulating α-tocopherol/β-cyclodextrin inclusion complex (α-TC/β-CD-IC) which has high antioxidant activity and photostability was produced via electrospinning (PCL/α-TC/β-CD-IC-NF). The formation of α-TC/β-CD-IC was confirmed by XRD. Phase solubility studies showed An -type complex formation between α-TC and β-CD. SEM revealed that bead-free nanofibers were successfully produced from PCL/α-TC/β-CD-IC system. PCL nanofibers encapsulating α-TC without CD-IC was also produced for comparison (PCL/α-TC-NF). Antioxidant test results showed that PCL/α-TC/β-CD-IC-NF had higher antioxidant activity as compared to PCL/α-TC-NF in methanol:water (1:1) system due to the stabilization and solubility increment of α-TC in the cavity of β-CD. PCL/α-TC/β-CD-IC-NF was more stable against UV-light when compared to PCL/α-TC-NF due to the presence of inclusion complexation. In brief, PCL/α-TC/β-CD-IC-NF with the advantages of having nanofibrous structure and encapsulating CD-ICs, may serve as a novel route for administration of α-TC due to its higher antioxidant activity and better UV-light stability.