Diagenesis-inspired reaction of magnesium ions with surface enamel mineral modifies properties of human teeth. (June 2016)

• Record Type: Journal Article
• Authors: Abdallah, Mohamed-Nur; Eimar, Hazem; Bassett, David C.; Schnabel, Martin; Ciobanu, Ovidiu; Nelea, Valentin; McKee, Marc D.; Cerruti, Marta; Tamimi, Faleh
• Is Part Of: Acta biomaterialia. Volume 37(2016)
• Page Start: 174
• Page End: 183
• Publication Date: 2016-06
• Subjects: Mineralized tissues -- Tooth enamel -- Ionic exchange -- Hypersaline environment -- Magnesium ions -- Crystallographic structure; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1016/j.actbio.2016.04.005
• Languages: English
• ISSNs: 1742-7061

Abstract

Graphical abstract: Abstract: Mineralized tissues such as teeth and bones consist primarily of highly organized apatitic calcium-phosphate crystallites within a complex organic matrix. The dimensions and organization of these apatite crystallites at the nanoscale level determine in part the physical properties of mineralized tissues. After death, geological processes such as diagenesis and dolomitization can alter the crystallographic properties of mineralized tissues through cycles of dissolution and re-precipitation occurring in highly saline environments. Inspired by these natural exchange phenomena, we investigated the effect of hypersalinity on tooth enamel. We discovered that magnesium ions reacted with human tooth enamel through a process of dissolution and re-precipitation, reducing enamel crystal size at the surface of the tooth. This change in crystallographic structure made the teeth harder and whiter. Salt-water rinses have been used for centuries to ameliorate oral infections; however, our discovery suggests that this ancient practice could have additional unexpected benefits. Statement of Significance: Here we describe an approach inspired by natural geological processes to modify the properties of a biomineral – human tooth enamel. In this study we showed that treatment of human tooth enamel with solutions saturated with magnesium induced changes in the nanocrystals at the outer surface of the protective enamel layer. As a consequence, the physical properties of the tooth were modified; tooth microhardness increased and the color shade became whiter, thus suggesting that this method could be used as a clinical treatment to improve dental mechanical properties and esthetics. Such an approach is simple and straightforward, and could also be used to develop new strategies to synthesize and modify biominerals for biomedical and industrial applications.