Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation. (July 2016)

• Record Type: Journal Article
• Authors: Fox, Carly; Lambie, Duncan; Wilmott, James S.; Pinder, Alex; Pavey, Sandra; Lê Cao, Kim‐Anh; Akalin, Taner; Karaarslan, Isil Kilinc; Ozdemir, Fezal; Scolyer, Richard A.; Yamada, Miko; Soyer, H Peter; Schaider, Helmut; Gabrielli, Brian
• Is Part Of: Pigment cell & melanoma research. Volume 29:Number 4(2016:Jul.)
• Page Start: 444
• Page End: 452
• Publication Date: 2016-07
• Subjects: naevi -- transformation -- markers; Melanoma -- Periodicals; Chromatophores -- Periodicals; Animal pigments -- Periodicals; 616.99477
• DOI: 10.1111/pcmr.12489
• Languages: English
• ISSNs: 1755-1471

Abstract

Summary: Here we have carried out a multiparameter analysis using a panel of 28 immunohistochemical markers to identify markers of transformation from benign and dysplastic naevus to primary melanoma in three separate cohorts totalling 279 lesions. We have identified a set of eight markers that distinguish naevi from melanoma. None of markers or parameters assessed differentiated benign from dysplastic naevi. Indeed, the naevi clustered tightly in terms of their immunostaining patterns whereas primary melanomas showed more diverse staining patterns. A small subset of histopathologically benign lesions had elevated levels of multiple markers associated with melanoma, suggesting that these represent naevi with an increased potential for transformation to melanoma.