The evolving roles and controversies of radiotherapy in the treatment of glioblastoma. Issue 2 (21st January 2016)

• Record Type: Journal Article
• Authors: Hau, Eric; Shen, Han; Clark, Catherine; Graham, Peter H.; Koh, Eng‐Siew; L. McDonald, Kerrie
• Is Part Of: Journal of medical radiation sciences. Volume 63:Issue 2(2016:Jun.)
• Page Start: 114
• Page End: 123
• Publication Date: 2016-01-21
• Subjects: Brain tumour -- glioblastoma -- radiation -- radiotherapy; Radiology, Medical -- Periodicals; Radiology, Medical -- Australia -- Periodicals; Radiology, Medical -- New Zealand -- Periodicals; Radiotherapy -- Periodicals; Diagnostic imaging -- Periodicals; 616
• DOI: 10.1002/jmrs.149
• Languages: English
• ISSNs: 2051-3895

Abstract

Abstract: Numerous randomised controlled trials have demonstrated the benefit of radiation therapy in patients with newly diagnosed glioblastoma and it has been the cornerstone of treatment for decades. The aims of this review are to (1) Briefly outline the historical studies which resulted in radiation being the current standard of care as used in the Stupp et al. trial (2) Discuss the evolving role of radiation therapy in the management of elderly patients (3) Review the current evidence and ongoing studies of radiation use in the recurrent/salvage setting and (4) Discuss the continuing controversies of volume delineation in the planning of radiation delivery. Abstract : The aims of this review are to (1) Briefly outline the historical studies which resulted in radiation being the current standard of care as used in the Stupp et al. trial (2) Discuss the evolving role of radiation therapy in the management of elderly patients (3) Review the current evidence and ongoing studies of radiation use in the recurrent/salvage setting and (4) Discuss the continuing controversies of volume delineation in the planning of radiation delivery.