Prevalence of migraine in persons with the 3243A>G mutation in mitochondrial DNA. (5th October 2015)

• Record Type: Journal Article
• Authors: Guo, S.; Esserlind, A.‐L.; Andersson, Z.; Frederiksen, A. L.; Olesen, J.; Vissing, J.; Ashina, M.
• Is Part Of: European journal of neurology. Volume 23:Number 1(2016:Jan.)
• Page Start: 175
• Page End: 181
• Publication Date: 2015-10-05
• Subjects: headache -- mDNA 3243A>G -- migraine -- mitochondrial dysfunction -- mutation; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12832
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract : Background and purpose: Over the last three decades mitochondrial dysfunction has been postulated to be a potential mechanism in migraine pathogenesis. The lifetime prevalence of migraine in persons carrying the 3243A>G mutation in mitochondrial DNA was investigated. Methods: In this cross‐sectional study, 57 mDNA 3243A>G mutation carriers between May 2012 and October 2014 were included. As a control group, a population‐based cohort from our epidemiological studies on migraine in Danes was used. History of headache and migraine was obtained by telephone interview, based on a validated semi‐structured questionnaire, performed by trained physicians. Results: The prevalence of migraine is significantly higher in persons carrying the 3243A>G mutation than in controls (58% vs. 18%; P < 0.001). This applies for both subforms of migraine, migraine without aura (47% vs. 12%; P < 0.001) and migraine with aura (18% vs. 6%; P < 0.001), and in females (58% vs. 24%; P < 0.001) and males (58% vs. 12%; P < 0.001) for any migraine. Conclusions: A high prevalence of migraine in persons with the mDNA 3243A>G mutation was found. This finding suggests a clinical association between a monogenetically inherited disorder of mitochondrial dysfunction and susceptibility to migraine. Mitochondrial DNA aberrations may contribute to the pathogenesis of migraine.