DBU‐Mediated [3+2] Cycloaddition Reactions of Donor–Acceptor Cyclopropanes with Nitromethane: Efficient Strategy for the Construction of Isoxazole Skeletons. Issue 14 (20th April 2016)

• Record Type: Journal Article
• Authors: Xue, Shuwen; Liu, Jiaming; Wang, Cunde
• Is Part Of: European journal of organic chemistry. Issue 14(2016)
• Page Start: 2450
• Page End: 2456
• Publication Date: 2016-04-20
• Subjects: Cycloaddition -- Donor–acceptor systems -- Heterocycles -- Nitro compounds -- Strained molecules; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201600227
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A new DBU‐mediated [3+2] cycloaddition reaction has been developed using readily available donor–acceptor cyclopropanes and nitromethane. This approach provides a straightforward and efficient route to the construction of polysubstituted isoxazole scaffolds in high yields. Abstract : Polysubstituted isoxazole‐5‐carboxylates were synthesized by DBU‐mediated [3+2] cycloaddition reaction of readily available donor–acceptor cyclopropanes and nitromethane.