Chemotaxis during neural crest migration. (July 2016)

• Record Type: Journal Article
• Authors: Shellard, Adam; Mayor, Roberto
• Is Part Of: Seminars in cell & developmental biology. Volume 55(2016)
• Page Start: 111
• Page End: 118
• Publication Date: 2016-07
• Subjects: Chemotaxis -- Neural crest -- Collective migration -- SDF1/CXCL12 -- VEGF -- C3/C3aR; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.01.031
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Chemotaxis refers to the directional migration of cells towards external, soluble factors along their gradients. It is a process that is used by many different cell types during development for tissue organisation and the formation of embryonic structures, as well as disease like cancer metastasis. The neural crest (NC) is a multipotent, highly migratory cell population that contribute to a range of tissues. It has been hypothesised that NC migration, at least in part, is reliant on chemotactic signals. This review will explore the current evidence for proposed chemoattractants of NC cells, and outline mechanisms for the chemotactic response of the NC to them.