Potential roles of telocytes in lung diseases. (July 2016)

• Record Type: Journal Article
• Authors: Shi, Lin; Dong, Nian; Chen, Chengshui; Wang, Xiangdong
• Is Part Of: Seminars in cell & developmental biology. Volume 55(2016)
• Page Start: 31
• Page End: 39
• Publication Date: 2016-07
• Subjects: Telocytes -- lung diseases -- gene -- protein -- pathogenesis; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2016.02.008
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Telocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps), as shown by immune-positive staining against CD34, c-kit and vimentin. They were found in many organs of mammals, with potential biological functions, including the trachea and lung, even though the exact function remains unclear. Here, we give a historical overview of the TCs research field and summarize the latest findings associated with TCs, with a special focus on the recent progress about TCs specific gene and protein profiles that has been made in understanding that TCs may play a potential, but important, role in the pathogenesis of lung diseases.