Host and disease factors are associated with cognitive function in European HIV‐infected adults prior to initiation of antiretroviral therapy. Issue 6 (26th November 2015)

• Record Type: Journal Article
• Authors: Winston, A; Stöhr, W; Antinori, A; Arenas‐Pinto, A; Llibre, JM; Amieva, H; Cabié, A; Williams, I; Di Perri, G; Tellez, MJ; Rockstroh, J; Babiker, A; Pozniak, A; Raffi, F; Richert, L
• Other Names: Dedes Nikos investigator.; Chene Genevieve investigator.; Allavena Clotilde investigator.; Autran Brigitte investigator.; Bucciardini Raffaella investigator.; Vella Stefano investigator.; Horban Andrzej investigator.; Arribas Jose investigator.; Boffito Marta investigator.; Pillay Deenan investigator.; Franquet Xavier investigator.; Schwarze Siegfried investigator.; Grarup Jesper investigator.; Fischer Aurelie investigator.; Wallet Cedrick investigator.; Diallo Alpha investigator.; Molina Jean‐Michel investigator.; Saillard Juliette investigator.; Moecklinghoff Christiane investigator.; Stellbrink Hans‐Jurgen investigator.; Leeuwen Remko investigator.; Gatell Jose investigator.; Sandstrom Eric investigator.; Flepp Markus investigator.; Ewings Fiona investigator.; George Elizabeth C. investigator.; Hudson Fleur investigator.; Pearce Gillian investigator.; Quercia Romina investigator.; Rogatto Felipe investigator.; Leavitt Randi investigator.; Nguyen Bach‐Yen investigator.; Goebel Frank investigator.; Marcotullio Simone investigator.; Kaur Navrup investigator.; Sasieni Peter investigator.; Spencer‐Drake Christina investigator.; Peto Tim investigator.; Miller Veronica investigator.; Chêne Geneviève investigator.; Arnault Fabien investigator.; Boucherie Céline investigator.; Fischer Aurélie investigator.; Jean Delphine investigator.; Paniego Virginie investigator.; Rouch Elodie investigator.; Schwimmer Christine investigator.; Soussi Malika investigator.; Taieb Audrey investigator.; Termote Monique investigator.; Touzeau Guillaume investigator.; Wallet Cédrick investigator.; Cursley Adam investigator.; Dodds Wendy investigator.; Hoppe Anne investigator.; Kummeling Ischa investigator.; Pacciarini Filippo investigator.; Paton Nick investigator.; Russell Charlotte investigator.; Taylor Kay investigator.; Ward Denise investigator.; Aagaard Bitten investigator.; Eid Marius investigator.; Gey Daniela investigator.; Jensen Birgitte investigator.; Jakobsen Marie‐Louise investigator.; Jansson Per O. investigator.; Jensen Karoline investigator.; Joensen Zillah investigator.; Larsen Ellen investigator.; Pahl Christiane investigator.; Pearson Mary investigator.; Nielsen Birgit investigator.; Reilev Søren investigator.; Christ Ilse investigator.; Lathouwers Desiree investigator.; Manting Corry investigator.; Mendy Bienvenu investigator.; Metro Annie investigator.; Couffin‐Cadiergues Sandrine investigator.; Knellwolf Anne‐Laure investigator.; Palmisiano Lucia investigator.; Aznar Esther investigator.; Barea Cristina investigator.; Cotarelo Manuel investigator.; Esteban Herminia investigator.; Girbau Iciar investigator.; Moyano Beatriz investigator.; Ramirez Miriam investigator.; Saiz Carmen investigator.; Sanchez Isabel investigator.; Yllescas Maria investigator.; Binelli Andrea investigator.; Colasanti Valentina investigator.; Massella Maurizio investigator.; Anagnostou Olga investigator.; Gioukari Vicky investigator.; Touloumi Giota investigator.; Schmied Brigitte investigator.; Rieger Armin investigator.; Vetter Norbert investigator.; Wit Stephane investigator.; Florence Eric investigator.; Vandekerckhove Linos investigator.; Gerstoft Jan investigator.; Mathiesen Lars investigator.; Katlama Christine investigator.; Cabie Andre investigator.; Cheret Antoine investigator.; Dupon Michel investigator.; Ghosn Jade investigator.; Girard Pierre‐Marie investigator.; Goujard Cécile investigator.; Lévy Yves investigator.; Morlat Philippe investigator.; Neau Didier investigator.; Obadia Martine investigator.; Perre Philippe investigator.; Piroth Lionel investigator.; Reynes Jacques investigator.; Tattevin Pierre investigator.; Ragnaud Jean investigator.; Weiss Laurence investigator.; Yazdan Yazdanpanah investigator.; Yeni Patrick investigator.; Zucman David investigator.; Behrens Georg investigator.; Esser Stefan investigator.; Fätkenheuer Gerd investigator.; Hoffmann Christian investigator.; Jessen Heiko investigator.; Schmidt Reinhold investigator.; Stephan Christoph investigator.; Unger Stefan investigator.; Hatzakis Angelos investigator.; Daikos George L investigator.; Papadopoulos Antonios investigator.; Skoutelis Athamasios investigator.; Banhegyi Denes investigator.; Mallon Paddy investigator.; Mulcahy Fiona investigator.; Andreoni Massimo investigator.; Bonora Stefano investigator.; Castelli Francesco investigator.; Monforte Antonella investigator.; Galli Massimo investigator.; Lazzarin Adriano investigator.; Mazzotta Francesco investigator.; Carlo Torti investigator.; Vullo Vincenzo investigator.; Prins Jan investigator.; Richter Clemens investigator.; Verhagen Dominique investigator.; Eeden Arne investigator.; Doroana Manuela investigator.; Antunes Francisco investigator.; Maltez Fernando investigator.; Sarmento‐Castro Rui investigator.; Garcia Juan investigator.; Aldeguer José investigator.; Clotet Bonaventura investigator.; Domingo Pere investigator.; Gatell Jose M. investigator.; Knobel Hernando investigator.; Marquez Manuel investigator.; Miralles Martin investigator.; Portilla Joaquin investigator.; Soriano Vicente investigator.; Thalme Anders investigator.; Blaxhult Anders investigator.; Gisslen Magnus investigator.; Fox Julie investigator.; Gompels Mark investigator.; Herieka Elbushra investigator.; Johnson Margaret investigator.; Leen Clifford investigator.; Teague Alastair investigator.; Boyd Mark investigator.; Møller Nina investigator.; Frøsig Ellen investigator.; Moing Vincent investigator.; Wit Ferdinand W. N. M. investigator.; Kowalska Justyna investigator.; Berenguer Juan investigator.; Moreno Santiago investigator.; MuHller Nicolas J. investigator.; Török Estée investigator.; Post Frank investigator.; Angus Brian investigator.; Calvez Vincent investigator.; Boucher Charles investigator.; Collins Simon investigator.; Dunn David investigator.; Lambert Sidonie investigator.; Marcelin Anne‐Geneviève investigator.; Perno Carlo investigator.; White Ellen investigator.; Ammassari Adriana investigator.; Stoehr Wolgang investigator.; Schmidt Reinhold investigator.; Odermarsky Michal investigator.; Smith Colette investigator.; Thiébaut Rodolphe investigator.; LaSerna Bernardino investigator.; Castagna Antonella investigator.; Furrer Hans‐Jackob investigator.; Mocroft Amanda investigator.; Reiss Peter investigator.; Fragola Vincenzo investigator.; Lauriola Marco investigator.; Murri Rita investigator.; Nieuwkerk Pythia investigator.; Spire Bruno investigator.; Volny‐Anne Alain investigator.; West Brian investigator.; Maria Josep investigator.; Braggion Marco investigator.; Focà Emanuele investigator.;
• Is Part Of: HIV medicine. Volume 17:Issue 6(2016:Jul.)
• Page Start: 471
• Page End: 478
• Publication Date: 2015-11-26
• Subjects: antiretroviral naïve -- cognitive -- HIV -- neuropsychological tests; HIV infections -- Treatment -- Periodicals; HIV-positive persons -- Periodicals; HIV infections -- Treatment -- Decision making -- Periodicals; 616.9792
• DOI: 10.1111/hiv.12344
• Languages: English
• ISSNs: 1464-2662

Abstract

Abstract : Objectives: Deficits in cognitive function remain prevalent in HIV‐infected individuals. The aim of this European multicentre study was to assess factors associated with cognitive function in antiretroviral therapy (ART)‐naïve HIV‐infected subjects at the time of enrolment in the NEAT 001/Agence Nationale de Recherche sur le SIDA (ANRS) 143 study. Methods: Prior to starting ART, seven cognitive tests exploring domains including episodic memory, verbal fluency, executive function and psychomotor speed were administered with scores standardized to z ‐score using the study population sample mean and standard deviation. The primary measure was overall z ‐score average (NPZ). We assessed associations between baseline factors and test results using multivariable regression models. Results: Of 283 subjects with baseline cognitive assessments, 90% were male and 12% of black ethnicity. Median (interquartile range) age, years of education, years of known HIV infection, baseline CD4 count and baseline HIV RNA were 39 (31, 47) years, 13 (11, 17) years, 1 (0, 4) years, 344 (279, 410) cells/μL and 4.74 (4.28, 5.14) log10 HIV‐1 RNA copies/mL, respectively. Forty per cent were current smokers. Factors significantly associated with poorer overall cognitive performance in multivariable models included older age, shorter duration of education, black ethnicity, lower height, and lower plasma HIV RNA. Conclusions: In this large, European‐wide, ART‐naïve population with relatively preserved immunity and early HIV infection, cognitive function scores at the time of ART initiation were associated with demographic and HIV‐disease factors.