A General, Effcient and Green Procedure for Synthesis of Dihydropyrimidine‐5‐carboxamides in Low Melting Betaine Hydrochloride/Urea Mixture. Issue 6 (23rd March 2016)

• Record Type: Journal Article
• Authors: Liu, Peng; Hao, Jianwu; Zhang, Zhanhui
• Is Part Of: Chinese journal of chemistry. Volume 34:Issue 6(2016:Jun.)
• Page Start: 637
• Page End: 645
• Publication Date: 2016-03-23
• Subjects: low melting mixture -- deep eutectic solvent -- dihydropyrimidine‐5‐carboxamide -- green chemistry; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201500862
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract: A simple, facile and convenient strategy has been developed for the synthesis of dihydropyrimidine‐5‐carboxamides in low melting mixture of betaine hydrochloride/urea. In this procedure, the low melting mixture of betaine hydrochloride/urea plays a triple role: as a catalyst, solvent and reactant. The present green protocol has advantages such as high yield of products, short reaction times, operational simplicity, no chromatographic separation, eco‐friendliness, and applicability for large‐scale synthesis. Abstract : Dihydropyrimidine‐5‐carboxamide derivatives were effectively synthesized in low melting mixture of betaine hydrochloride/urea. In this procedure, the low melting mixture of betaine hydrochloride/urea plays a triple role: as a catalyst, solvent and reactant.