Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Marsh, Anthony P.; Applegate, William B.; Guralnik, Jack M.; Jack Rejeski, W.; Church, Timothy S.; Fielding, Roger A.; Gill, Thomas M.; King, Abby C.; Kritchevsky, Stephen B.; Manini, Todd M.; McDermott, Mary M.; Newman, Anne B.; Stowe, Cynthia L.; Walkup, Michael P.; Pahor, Marco; Miller, Michael E.
• Other Names: Leeuwenburgh Christiaan investigator.; Caudle Connie investigator.; Crump Lauren investigator.; Holmes Latonia investigator.; Lee Jocelyn investigator.; Lu Ching‐ju investigator.; Espeland Mark A. investigator.; Ambrosius Walter T. investigator.; Beavers Daniel P. investigator.; Byington Robert P. investigator.; Cook Delilah investigator.; Furberg Curt D. investigator.; Harvin Lea N. investigator.; Henkin Leora investigator.; Hepler John investigator.; Hsu Fang‐Chi investigator.; Lovato Laura investigator.; Roberson Wesley investigator.; Rushing Julia investigator.; Rushing Scott investigator.; Hire Don investigator.; Katula Jeffrey A. investigator.; Brubaker Peter H. investigator.; Mihalko Shannon L. investigator.; Jennings Janine M. investigator.; Hadley Evan C. investigator.; Romashkan Sergei investigator.; Patel Kushang V. investigator.; Bonds Denise investigator.; Spring Bonnie investigator.; Hauser Joshua investigator.; Kerwin Diana investigator.; Domanchuk Kathryn investigator.; Graff Rex investigator.; Rego Alvito investigator.; Blair Steven N. investigator.; Myers Valerie H. investigator.; Monce Ron investigator.; Britt Nathan E. investigator.; Harris Melissa Nauta investigator.; McGucken Ami Parks investigator.; Rodarte Ruben investigator.; Millet Heidi K. investigator.; Tudor‐Locke Catrine investigator.; Butitta Ben P. investigator.; Donatto Sheletta G. investigator.; Cocreham Shannon H. investigator.; Castro Cynthia M. investigator.; Haskell William L. investigator.; Stafford Randall S. investigator.; Pruitt Leslie A. investigator.; Berra Kathy investigator.; Yank Veronica investigator.; Nelson Miriam E. investigator.; Folta Sara C. investigator.; Phillips Edward M. investigator.; Liu Christine K. investigator.; McDavitt Erica C. investigator.; Reid Kieran F. investigator.; Kim Won S. investigator.; Beard Vince E. investigator.; Anton Stephen D. investigator.; Nayfield Susan investigator.; Buford Thomas W. investigator.; Marsiske Michael investigator.; Sandesara Bhanuprasad D. investigator.; Knaggs Jeffrey D. investigator.; Lorow Megan S. investigator.; Marena William C. investigator.; Korytov Irina investigator.; Morris Holly L. investigator.; Fitch Margo investigator.; Singletary Floris F. investigator.; Causer Jackie investigator.; Radcliff Katie A. investigator.; Studenski Stephanie A. investigator.; Goodpaster Bret H. investigator.; Glynn Nancy W. investigator.; Lopez Oscar investigator.; Nadkarni Neelesh K. investigator.; Williams Kathy investigator.; Newman Mark A. investigator.; Grove George investigator.; Bonk Janet T. investigator.; Rush Jennifer investigator.; Kost Piera investigator.; Ives Diane G. investigator.; Brinkley Tina E. investigator.; Demons Jamehl S. investigator.; Sink Kaycee M. investigator.; Kennedy Kimberly investigator.; Shertzer‐Skinner Rachel investigator.; Wrights Abbie investigator.; Fries Rose investigator.; Barr Deborah investigator.; Axtell Robert S. investigator.; Kashaf Susan S. investigator.; de Rekeneire Nathalie investigator.; McGloin Joanne M. investigator.; Wu Karen C. investigator.; Shepard Denise M. investigator.; Fennelly Barbara investigator.; Iannone Lynne P. investigator.; Mautner Raeleen investigator.; Barnett Theresa Sweeney investigator.; Halpin Sean N. investigator.; Brennan Matthew J. investigator.; Bugaj Julie A. investigator.; Zenoni Maria A. investigator.; Mignosa Bridget M. investigator.; Williamson Jeff investigator.; Sink Kaycee M investigator.; Hendrie Hugh C. investigator.; Rapp Stephen R. investigator.; Verghese Joe investigator.; Espeland Mark investigator.; Jennings Janine investigator.; Pepine Carl J. investigator.; Ariet Mario investigator.; Handberg Eileen investigator.; Deluca Daniel investigator.; Hill James investigator.; Szady Anita investigator.; Chupp Geoffrey L. investigator.; Flynn Gail M. investigator.; Hankinson John L. investigator.; Vaz Fragoso Carlos A. investigator.;
• Is Part Of: Journal of the American Geriatrics Society. Volume 64:Issue 5(2016:May)
• Page Start: 933
• Page End: 943
• Publication Date: 2016-05
• Subjects: physical activity -- older adults -- mobility disability -- safety -- hospitalizations; Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.14114
• Languages: English
• ISSNs: 0002-8614

Abstract

Abstract : Objectives: To determine whether moderate‐intensity physical activity (PA) and health education (HE) are differentially associated with categories of hospitalizations or subgroups of participants. Design: Multicenter randomized controlled trial in which participants were randomized to a PA or HE program for an average of 2.6 years. Setting: Eight field centers. Participants: Sedentary men and women aged 70–89 with lower extremity physical limitations but able to walk 400‐m in 15 minutes or less (N = 1, 635). Interventions: Structured, moderate‐intensity PA (n = 818) at a center (2×/wk) and at home (3–4×/wk) that included aerobic, strength, balance, and flexibility training or HE (n = 817) of educational workshops and upper extremity stretching exercises. Measurements: All‐cause inpatient hospitalizations ascertained at 6‐month intervals. Results: There were 1, 458 hospitalizations (49.1% of PA, 44.4% of HE; risk difference = 4.68%, 95% confidence interval (CI) = −0.18–9.54; hazard ratio (HR) = 1.16, 95% CI = 1.00–1.34). The intervention effect on incident hospitalization did not differ according to race, sex, Short Physical Performance Battery score, age, or history of cardiovascular disease or diabetes mellitus. PA was associated with higher rates of hospitalization in the middle baseline gait speed category, than HE (<0.8 m/s: HR = 0.93, 95% CI = 0.76–1.14; 0.8–1.0 m/s: HR = 1.54, 95% CI = 1.23–1.94; >1.0 m/s: HR = 1.05, 95% CI = 0.67–1.65; interaction P = .005). Conclusion: A PA program in older adults at risk for mobility disability did not lead to a different risk of specific types of hospitalizations than a HE program overall. Baseline gait speed may be a marker for risk of hospitalization during a PA intervention, because individuals with moderate baseline gait speed in the PA group had slightly higher rates of hospitalization than those in the HE group. Trial Registration: ClinicalTrials.gov identifier: NCT01072500.