Bayesian reclassification statistics for assessing improvements in diagnostic accuracy. (14th February 2016)

• Record Type: Journal Article
• Authors: Huang, Zhipeng; Li, Jialiang; Cheng, Ching‐Yu; Cheung, Carol; Wong, Tien‐Yin
• Is Part Of: Statistics in medicine. Volume 35:Number 15(2016)
• Page Start: 2574
• Page End: 2592
• Publication Date: 2016-02-14
• Subjects: logistic regression -- net reclassification improvement -- integrated discrimination improvement -- Bayesian estimation -- biomarker evaluation; Medical statistics -- Periodicals; Statistique médicale -- Périodiques; Statistiques médicales -- Périodiques; 610.727
• DOI: 10.1002/sim.6899
• Languages: English
• ISSNs: 0277-6715

Abstract

Abstract : We propose a Bayesian approach to the estimation of the net reclassification improvement (NRI) and three versions of the integrated discrimination improvement (IDI) under the logistic regression model. Both NRI and IDI were proposed as numerical characterizations of accuracy improvement for diagnostic tests and were shown to retain certain practical advantage over analysis based on ROC curves and offer complementary information to the changes in area under the curve. Our development is a new contribution towards Bayesian solution for the estimation of NRI and IDI, which eases computational burden and increases flexibility. Our simulation results indicate that Bayesian estimation enjoys satisfactory performance comparable with frequentist estimation and achieves point estimation and credible interval construction simultaneously. We adopt the methodology to analyze a real data from the Singapore Malay Eye Study. Copyright © 2016 John Wiley & Sons, Ltd.