Nanoarchitectured Electrochemical Cytosensor for Selective Detection of Cancer Cells. Issue 7 (25th May 2016)

• Record Type: Journal Article
• Authors: Meng, Fanyu; Han , Kun; Wang, Bidou; Liu , Tao; Liu, Guangxing; Li, Yueran; Miao , Peng
• Is Part Of: ChemistrySelect. Volume 1:Issue 7(2016)
• Page Start: 1515
• Page End: 1517
• Publication Date: 2016-05-25
• Subjects: Aptamers -- cancer cells -- DNA nanostructure -- silver nanoparticles -- voltammetry; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201600193
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Cancer progress monitoring for early diagnosis and prevention of relapse is highly desirable for human health. Developing effective methods to detect cancer cells are urgent tasks for clinical applications. In this case, a nanoarchitectured electrochemical cytosensor for selective detection of cancer cells is investigated. Generally, DNA tetrahedron nanostructure assembles on a gold electrode and the aptamer sequence on top of the scaffold can capture cancer cells selectively. By further loading of Cys‐Arg‐Gly‐Asp‐Ser (CRGDS) modified silver nanoparticles (AgNPs) on the cells, a sandwich structure forms and the stripping current from AgNPs is recorded to reflect the level of cancer cells. This simply constructed electrochemical cytosensor shows good performance for cancer cells analysis, which is attributed to the combination of DNA tetrahedron nanostructure and stripping analysis. Therefore, this proposed method may have potential applications for improving cancer diagnosis. Abstract : An electrochemical cytosensor for selective detection of cancer cells is investigated based on DNA tetrahedron nanostructure as the scaffold on the electrode and aptamer sequence on top as the recognition element. By further loading of CRGDS modified silver nanoparticles as signal sources, excellent performance for cancer cells analysis is achieved. This proposed method may have potential applications for improving cancer diagnosis.