A Novel C22 Terpenoid from the Cultured Perovskia atriplicifolia. Issue 6 (24th May 2016)

• Record Type: Journal Article
• Authors: Jiang, Zhi‐Yong; Zhu, Le‐Yu; Zhou, Jun; Hu, Qiu‐Fen; Yang, Guang‐Yu; Huang, Xiang‐Zhong; Liu, Wen‐Xing; Gao, Lu; Li, Gan‐Peng; Xia, Fu‐Ting
• Is Part Of: Helvetica chimica acta. Volume 99:Issue 6(2016:Jun.)
• Page Start: 452
• Page End: 456
• Publication Date: 2016-05-24
• Subjects: Perovskia atriplicifolia -- Terpenoids -- Cytotoxic activities -- Structure elucidation; Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201500514
• Languages: English
• ISSNs: 0018-019X

Abstract

Abstract : A novel terpenoid, named perovskiaol (1 ), was isolated from the cultured Perovskia atriplicifolia . Its structure was elucidated by comprehensive spectroscopic analysis as well as by quantum chemical computation of electronic circular dichroism spectra. Perovskiaol (1 ) was a novel C22 terpenoid containing a unique D ‐ring simultaneously fused with rings A, B, and C, and encountered in nature for the first time. Cytotoxic bioassay suggested perovskiaol (1 ) possessed significant cytotoxic activity inhibiting NB4, A549, and HepG 2 cell lines with IC 50 values of 2.35, 1.47, and 0.81 μm, respectively. Abstract :