Injury, inflammation and the emergence of human‐specific genes. Issue 3 (4th April 2016)

• Record Type: Journal Article
• Authors: Baird, Andrew; Costantini, Todd; Coimbra, Raul; Eliceiri, Brian P.
• Is Part Of: Wound repair and regeneration. Volume 24:Issue 3(2016)
• Page Start: 602
• Page End: 606
• Publication Date: 2016-04-04
• Subjects: Wound healing -- Periodicals; Regeneration (Biology) -- Periodicals; 617.14
• DOI: 10.1111/wrr.12422
• Languages: English
• ISSNs: 1067-1927

Abstract

Abstract: In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human‐specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human‐specific signaling pathways in experimental models of injury and infers that a selection of human‐specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.