Prevalence of celiac disease in Asia: A systematic review and meta‐analysis. Issue 6 (June 2016)

• Record Type: Journal Article
• Authors: Singh, Prashant; Arora, Shubhangi; Singh, Alka; Strand, Tor A; Makharia, Govind K
• Is Part Of: Journal of gastroenterology and hepatology. Volume 31:Issue 6(2016:Jun.)
• Page Start: 1095
• Page End: 1101
• Publication Date: 2016-06
• Subjects: anti‐endomysial -- China -- gluten -- India -- screening -- tissue transglutaminase; Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.13270
• Languages: English
• ISSNs: 0815-9319

Abstract

Abstract: Background and Aim: Celiac disease (CD) is emerging in Asia. While a few population‐based studies from Asia have reported a prevalence of CD from 0.1% to 1.3%, the exact prevalence of CD in Asia is not known. We conducted a systematic review and meta‐analysis to estimate the prevalence of CD in Asia. Methods: On search of literature, we found 1213 articles, of which 18 articles were included. Diagnosis of CD was based on European Society of Pediatric Gastroenterology, Hepatology and Nutrition guidelines. Results: Pooled sero‐prevalence of CD in Asia was 1.6% in 47 873 individuals based on positive anti‐tissue transglutaminase and/or anti‐endomysial antibodies. Pooled prevalence of biopsy proven CD in Asia was 0.5% in 43 955 individuals. The prevalence of CD among women was higher than in men (0.5% vs 0.4%, P = 0.04). The pooled prevalence of CD was 0.3% in Iran, 0.5% in Turkey, 0.6% in India, and 0.7% in Israel. The pooled prevalence of CD was significantly higher in Israel and India as compared with that in Iran. Conclusions: Celiac disease is not uncommon in Asia, and the sero‐prevalence and prevalence of CD in Asia are 1.6% and 0.5%, respectively. The prevalence of CD varies with gender and geographic location. There is a need for population‐based prevalence studies in many Asian countries to properly estimate the burden of CD in Asia.