Can chronic myeloid leukaemia in children and adolescents be successfully treated without haematopoietic stem cell transplant? A single centre experience. (23rd February 2016)

• Record Type: Journal Article
• Authors: Giona, Fiorina; Moleti, Maria L.; De Benedittis, Daniela; Santopietro, Michelina; Nanni, Mauro; Testi, Anna M.; Orlando, Sonia; Iori, Anna P.; Piciocchi, Alfonso; Gottardi, Enrico; Barberi, Walter; Diverio, Daniela; Saglio, Giuseppe; Foà, Robin
• Is Part Of: British journal of haematology. Volume 173:Number 5(2016)
• Page Start: 749
• Page End: 753
• Publication Date: 2016-02-23
• Subjects: CML -- childhood leukaemia -- tyrosine kinase inhibitors -- interferon -- haematopoietic stem cell transplantation; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.13991
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: We analysed the long‐term outcome of 35 children and adolescents (<20 years at diagnosis) with chronic myeloid leukaemia (CML) in chronic phase: 20 patients had received interferon‐alpha and/or tyrosine kinase inhibitors (TKIs), and 15 underwent a haematopoietic stem cell transplant. The 10‐year survival probabilities were similar in transplanted and non‐transplanted patients (73·3% vs. 72·1%, respectively), whereas the survival probability was significantly lower in patients diagnosed before 1999 compared to those diagnosed afterwards (62·1% vs. 100%, P = 0·0384). The availability of TKIs and the standardized molecular monitoring have significantly improved treatment, management and outcome in children and adolescents with CML.