Biomarkers for sporadic Creutzfeldt–Jakob disease. Issue 6 (25th April 2016)

• Record Type: Journal Article
• Authors: Soomro, Sanam; Mohan, Chandra
• Is Part Of: Annals of clinical and translational neurology. Volume 3:Issue 6(2016)
• Page Start: 465
• Page End: 472
• Publication Date: 2016-04-25
• Subjects: Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1002/acn3.304
• Languages: English
• ISSNs: 2328-9503

Abstract

Abstract: Sporadic Creutzfeldt–Jakob disease (sCJD) is a rare but fatal type of spongiform encephalopathy with unknown cause. Unfortunately, definitive diagnosis of this disease can only be done by examination of postmortem brain tissue. Presumptive diagnosis is done through a combination of clinical manifestations, radiology results, and cerebrospinal fluid (CSF) testing for CSF 14‐3‐3. Even with these guidelines, premortem diagnosis of sCJD can be unreliable with high rates of misdiagnosis. This calls for more reliable biomarkers of the disease, allowing for better diagnosis as well as understanding the pathogenesis of sCJD. This review compiles potential genetic, protein, biomolecular, and imaging biomarker studies for sCJD since 2010, highlighting the promise of proteins, cytokines, and composite biomarkers for improving the diagnosis as well as understanding the pathogenesis of this mysterious ailment.