Dimensional assessment of behavioral changes in the cuprizone short-term exposure model for psychosis. (June 2016)

• Record Type: Journal Article
• Authors: Kondo, Mari A.; Fukudome, Daisuke; Smith, Dani R.; Gallagher, Michela; Kamiya, Atsushi; Sawa, Akira
• Is Part Of: Neuroscience research. Volume 107(2016:Jun.)
• Page Start: 70
• Page End: 74
• Publication Date: 2016-06
• Subjects: CON control -- CSE cuprizone short-term exposure -- DSM Diagnostic and Statistical Manual of Mental Disorders -- ED exposure day -- FST forced swim test -- GFAP glial fibrillary acidic protein -- Iba1 ionized calcium-binding adaptor molecule 1 -- IL-6 interleukin-6 -- LPS lipopolysaccharide -- MIA maternal immune activation -- poly(I:C) polyriboinosinic-polyribocytidilic acid -- RDoC Research Domain Criteria -- TST tail suspension test; Cuprizone -- Cuprizone short-term exposure (CSE) -- Psychosis -- Behavior -- Inflammation -- Hippocampus -- Research Domain Criteria (RDoC) -- Dimensional approach; Neurosciences -- Research -- Periodicals; Neurosciences -- Research -- Japan -- Periodicals; Neurology -- Periodicals; Neurosciences -- Periodicals; Neurosciences -- Recherche -- Périodiques; Neurosciences -- Recherche -- Japon -- Périodiques; Neurosciences -- Research; Japan; Periodicals; 612.8
• DOI: 10.1016/j.neures.2016.01.006
• Languages: English
• ISSNs: 0168-0102

Abstract

Highlights: Cuprizone short-term exposure (CSE) models brain inflammation-associated psychosis. Comprehensive behavior assessment of CSE model is done using a dimensional approach. The CSE model may be useful to further our understanding of psychosis mechanisms. Abstract: Recent clinical studies have suggested a role for immune/inflammatory responses in the pathophysiology of psychosis. However, a mechanistic understanding of this process and its application for drug discovery is underdeveloped. Here we assessed our recently developed cuprizone short-term exposure (CSE) mouse model across behavioral domains targeting neurocognitive and neuroaffective systems. We propose that the CSE model may be useful for understanding the mechanism associating inflammation and psychosis, with applications for drug discovery in that context.