Persistent Multiyear Control of Relapsed T‐Cell Acute Lymphoblastic Leukemia With Successive Donor Lymphocyte Infusions: A Case Report. Issue 7 (14th March 2016)

• Record Type: Journal Article
• Authors: Huo, Jeffrey S.; Symons, Heather J.; Robey, Nancy; Borowitz, Michael J.; Schafer, Eric S.; Chen, Allen R.
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 7(2016)
• Page Start: 1279
• Page End: 1282
• Publication Date: 2016-03-14
• Subjects: donor lymphocyte infusion -- haploidentical bone marrow transplant -- relapse -- T‐cell acute lymphoblastic leukemia; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25971
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : There are few therapeutic options for patients with T‐cell acute lymphoblastic leukemia (T‐ALL) who have recurrent disease after initial matched sibling hematopoietic stem cell transplantation. While a second hematopoietic stem cell transplant (HSCT) from a haploidentical donor offers the conceptual possibility of greater graft versus leukemia effect, there is minimal literature to describe the efficacy of this approach in recurrent pediatric T‐ALL. We present the case of a now 9‐year‐old female in whom second haploidentical HSCT, followed by successive donor lymphocyte infusions in response to minimal residual disease reemergence, has led to 3+ years of ongoing disease control without graft versus host disease and excellent quality of life.