Synthesis of 2, 5‐Hexanedione from Biomass Resources Using a Highly Efficient Biphasic System. Issue 6 (11th May 2016)

• Record Type: Journal Article
• Authors: Li , Yueqin; Lv , Guangqiang; Wang , Yuqi; Deng, Tiansheng; Wang, Yingxiong; Hou, Xianglin; Yang, Yongxing
• Is Part Of: ChemistrySelect. Volume 1:Issue 6(2016)
• Page Start: 1252
• Page End: 1255
• Publication Date: 2016-05-11
• Subjects: 2, 5-hexanedione -- 2, 5-dimethylfuran -- bi-phase -- Bronsted acids -- biomass conversation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201600280
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: 2, 5‐hexanedione, a valuable platform chemical which is being broadly used in biofuel, medicinal chemistry and drug discovery, was synthesized from biomass derived dimethyl furane using a highly efficient biphasic system. In this biphasic systems, mineral acids (HCl, H2 SO4 and H3 PO4 ) dissolved in aqueous phase were used as hydrolysis catalysts. The hydrolysis reaction is suggested to take place at the interface between the aqueous and the organic phase. But more importantly, water‐immiscible organic phase could continuously extract the in‐situ produced 2, 5‐hexanedione from the interface to prevent the extended contact between the 2, 5‐hexanedione and the acids, thereby avoiding the oligomerization side reactions A yield of 99 % could be obtained when methyl isobutyl ketone (MIBK) was the organic phase in the biphasic system. Abstract : 2, 5‐hexanedione, a valuable platform chemical which is being broadly used in biofuel, medicinal chemistry and drug discovery, was synthesized from biomass derived dimethyl furane using a highly efficient biphasic system. Water‐immiscible organic phase could continuously extract the in‐situ produced 2, 5‐hexanedione from the interface to prevent the extended contact between the 2, 5‐hexanedione and the acids, thereby avoiding the oligomerization side reactions.