Inside Cover: Modular Combination of Enzymatic Halogenation of Tryptophan with Suzuki–Miyaura Cross‐Coupling Reactions (ChemCatChem 10/2016). Issue 10 (20th May 2016)

• Record Type: Journal Article
• Authors: Frese, Marcel; Schnepel, Christian; Minges, Hannah; Voß, Hauke; Feiner, Rebecca; Sewald, Norbert
• Is Part Of: ChemCatChem. Volume 8:Issue 10(2016)
• Page Start: 1749
• Page End: 1749
• Publication Date: 2016-05-20
• Subjects: biocatalysis -- enzyme catalysis -- cross-coupling -- multicomponent reactions -- palladium; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201600526
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract : The Cover highlights the cascade combination of biocatalysis with metal catalysis. In their Full Paper, M. Frese et al. explain that regioselective enzymatic halogenation ofl ‐tryptophan followed by Suzuki‐Miyaura cross‐coupling leads, in a modular synthesis, to an array of C5, C6, or C7 aryl‐substituted tryptophan derivatives. The bromo substituent is initially being incorporated by immobilized tryptophan 5‐, 6‐, or 7‐halogenases, in aqueous media, using only oxygen and a halide source. Workup is not required: the solid biocatalyst is just removed by filtration and the filtrate is used to directly convert the halogenated tryptophan into the cross‐coupling products. More information can be found in the Full Paper by M. Frese et al. onpage 1799 in Issue 10, 2016 (DOI:10.1002/cctc.201600317 ).