Antibody responses following incident anal and penile infection with human papillomavirus in teenage men who have sex with men. Issue 3 (4th April 2016)

• Record Type: Journal Article
• Authors: Zou, Huachun; Tabrizi, Sepehr N.; Grulich, Andrew E.; Hocking, Jane S.; Garland, Suzanne M.; Bradshaw, Catriona S.; Cornall, Alyssa M.; Fairley, Christopher K.; Chen, Marcus Y.
• Is Part Of: International journal of cancer. Volume 139:Issue 3(2016:Aug. 01)
• Page Start: 639
• Page End: 646
• Publication Date: 2016-04-04
• Subjects: human papillomavirus (HPV) -- men who have sex with men -- seroprevalence -- seroincidence -- antibody; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.30093
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : Men who have sex with men (MSM) are at risk for human papillomavirus (HPV)‐related anal cancer. Few data exist on antibody responses following incident anogenital infection with HPV in teenage MSM. A cohort of 200 MSM aged 16–20 years from Melbourne, Australia were assessed at baseline, 3, 6 and 12 months. At each visit anal and penile swabs were collected for HPV DNA and serum for HPV antibodies for genotypes 6, 11, 16 and 18 (Merck's Multiplex Assays using Luminex). The main outcome, seroconversion, was defined as the detection of HPV antibodies following a negative antibody result for the same HPV type at baseline. The seroincidence rates for HPV types 6, 11, 16 and 18 were: 19 (95% CI 12–26), 7 (3–12), 4 (1–8) and 6 (3–11) per 100 person‐years, respectively. Men who experienced incident anal HPV infections from types 6/11 were significantly more likely to develop serum antibodies to the same HPV type(s) than those who experienced incident anal infections from types 16/18 [73 vs . 18%, odds ratio (OR) = 15, 95% CI: 2–118]. The median time between incident anal HPV infection and seroconversion for HPV 6, 11, 16 and 18 was: 91, 38, 161 and 182 days, respectively. Antibody responses against HPV types 6/11 were significantly more likely to occur following incident anal compared with incident penile infection with HPV types 6/11 (OR = 6, 95% CI: 2–21). The likelihood of antibody responses following anogenital HPV infections depends on the HPV type and site of infection. Abstract : What's new? Antibody responses can protect from repeat infections with high‐risk human papilloma virus (HPV), but their development after anal infection is less well studied. Here the authors examine HPV antibody responses (genotypes 6, 11, 16 and 18) following incident anal or penile infection within a cohort of teenage men who have sex with men in the very early stages of their sexual careers. The data uncover different likelihoods for antibody responses depending on viral genotype and the site of infection.