Front Cover Picture: Catalytic One‐Pot Oxetane to Carbamate Conversions: Formal Synthesis of Drug Relevant Molecules (Adv. Synth. Catal. 10/2016). Issue 10 (1st April 2016) - Guo, Wusheng
Abstract : The front cover picture, provided by Arjan Kleij and co‐workers, illustrates oxetane‐based carbamates: oxetane‐based carbamate scaffolds are formed using an efficient aluminium catalyst. The process combines three reagents (CO2, oxetanes and amines) in a one‐pot approach towards a wide diversity of carbamate structures. The methodology has been applied in the formal synthesis of drug‐relevant molecules such as Carisoprodol and the mono‐carbamate of Felbatol showing the utility of the new catalytic procedure. The work also illustrates the potential of oxetanes as versatile reagents in pharma‐organic synthesis. Details can be found in the full paper onpages 1602–1607 (W. Guo, V. Laserna, J. Rintjema, A. W. Kleij, Adv. Synth. Catal. 2016, 358, 1602–1607; DOI:10.1002/adsc.201500895 ).