Differentiating locally recurrent rectal cancer from scar tissue: Value of diffusion-weighted MRI. Issue 7 (July 2016)

• Record Type: Journal Article
• Authors: Grosu, Sergio; Schäfer, Arnd-Oliver; Baumann, Tobias; Manegold, Philipp; Langer, Mathias; Gerstmair, Axel
• Is Part Of: European journal of radiology. Volume 85:Issue 7(2016)
• Page Start: 1265
• Page End: 1270
• Publication Date: 2016-07
• Subjects: ADC apparent diffusion coefficient -- AUC area under curve -- CRTx chemoradiotherapy -- CTx chemotherapy -- CT computed tomography -- DWI diffusion-weighted imaging -- EPI echo planar imaging -- EPSE single-shot epi-diffusion-weighted sequence -- FOV field of view -- GRAPPA generalized autocalibrating partially parallel acquisition -- iPAT integrated parallel imaging techniques -- MRI magnetic resonance imaging -- ROC receiver operating characteristic -- ROI region of interest -- TE echo time -- TR repetition time -- TSE turbo spin echo; Rectal cancer -- Magnetic resonance imaging -- Diffusion weighted MRI -- Recurrence -- Scar; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2016.04.006
• Languages: English
• ISSNs: 0720-048X

Abstract

Highlights: DWI helps in distinguishing local recurrence from scar-tissue in rectal cancer. The cut-off value for tumour vs. scar-tissue ADC was 1.34 × 10 −3 mm 2 /s. Statistical fortification of the diagnosis. Abstract: Objectives: To determine a cut-off apparent diffusion coefficient (ADC) value distinguishing local recurrence from scar tissue in patients with rectal cancer treated with complete surgical tumour removal. Methods: 72 patients were retrospectively included. Patients underwent 1.5T MRI including multiplanar T2-weighted turbo-spin-echo sequences (TSE) and axial single-shot epi-diffusion-weighted sequences (EPSE). Two independent observers measured mean tumour and scar tissue ADCs by manually drawing regions of interest (ROIs). The t -test and ROC analysis were used for comparison and determining an optimal discrimination threshold. As reference standard histopathological results were used in 23 patients (32%) and clinical follow-up in 49 patients (68%). Results: Recurrent rectal cancer was found in 30 patients (4 female, 26 male, median age 63.13 years) and treatment related changes such as scar tissue in 42 patients (11 female, 31 male, median age 63.67 years). The mean ADC value of tumour recurrence was 1.02 × 10 −3 mm 2 /s (0.63–1.44 × 10 −3 mm 2 /s) and of scar tissue 1.77 × 10 −3 mm 2 /s (1.11–2.41 × 10 −3 mm 2 /s) showing a statistically significant difference (p < 0.001). The cut-off ADC value was 1.34 × 10 −3 mm 2 /s with a sensitivity, specificity, and accuracy of 93%, 91%, and 92% respectively. Conclusions: Diffusion weighted MRI allows for the differentiation of tumour recurrence from scar tissue after surgical resection of rectal cancer.