The Wnt7's Tale: A story of an orphan who finds her tie to a famous family. Issue 5 (7th April 2016)
- Record Type:
- Journal Article
- Title:
- The Wnt7's Tale: A story of an orphan who finds her tie to a famous family. Issue 5 (7th April 2016)
- Main Title:
- The Wnt7's Tale: A story of an orphan who finds her tie to a famous family
- Authors:
- Noda, Makoto
Vallon, Mario
Kuo, Calvin J. - Abstract:
- Abstract : The transformation suppressor gene RECK was isolated by cDNA expression cloning (1998), and GPR124/TEM5 was detected as a tumor endothelial marker by differential screening (2000). The importance of Wnt7a/b and Gpr124 in brain angiogenesis was demonstrated by reverse genetics in mice (2008–2010). A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assays in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a/b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis and blood–brain barrier formation. Abstract : A series of recent studies using genetically engineered mice and zebrafish as well as luciferase reporter assay in cultured cells led to the discovery of functional interactions among Reck, Gpr124, and Wnt7a/b in triggering canonical Wnt signaling with relevance to embryonic brain angiogenesis.
- Is Part Of:
- Cancer science. Volume 107:Issue 5(2016)
- Journal:
- Cancer science
- Issue:
- Volume 107:Issue 5(2016)
- Issue Display:
- Volume 107, Issue 5 (2016)
- Year:
- 2016
- Volume:
- 107
- Issue:
- 5
- Issue Sort Value:
- 2016-0107-0005-0000
- Page Start:
- 576
- Page End:
- 582
- Publication Date:
- 2016-04-07
- Subjects:
- Angiogenesis -- Gpr124 -- Reck -- Wnt7a/b -- zebrafish
Cancer -- Periodicals
Neoplasms -- Periodicals
Research -- Periodicals
Electronic journals
616.994005 - Journal URLs:
- http://firstsearch.oclc.org ↗
http://firstsearch.oclc.org/journal=1347-9032;screen=info;ECOIP ↗
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1349-7006 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/cas.12924 ↗
- Languages:
- English
- ISSNs:
- 1347-9032
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3046.603000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 2064.xml