Current status and future directions of T‐lymphoblastic lymphoma in children and adolescents. (15th March 2016)

• Record Type: Journal Article
• Authors: Burkhardt, Birgit; Mueller, Stephanie; Khanam, Tasneem; Perkins, Sherrie L.
• Other Names: Cairo Mitch guestEditor.; Pinkerton Ross guestEditor.
• Is Part Of: British journal of haematology. Volume 173:Number 4(2016)
• Page Start: 545
• Page End: 559
• Publication Date: 2016-03-15
• Subjects: Paediatric T‐lymphoblastic lymphoma -- molecular markers -- risk group stratification -- genetic classifier -- treatment; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.14017
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: The main challenges in the treatment of T‐cell lymphoblastic lymphoma (T‐LBL) in children and adolescents are twofold: to increase survival rates in concert with reduction of acute and long‐term toxicities including the rate of secondary malignancies. The need for molecular and prognostic markers in T‐LBL is crucial to allow for systematic treatment optimization and may serve as targets for new treatment approaches.