Nutritional interventions for Alzheimer's prevention: a clinical precision medicine approach. Issue 1 (March 2016)

• Record Type: Journal Article
• Authors: Schelke, Matthew W.; Hackett, Katherine; Chen, Jaclyn L.; Shih, Chiashin; Shum, Jessica; Montgomery, Mary E.; Chiang, Gloria C.; Berkowitz, Cara; Seifan, Alon; Krikorian, Robert; Isaacson, Richard Scott
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1367:Issue 1 (2016)
• Page Start: 50
• Page End: 56
• Publication Date: 2016-03
• Subjects: preclinical Alzheimer's disease -- Alzheimer's prevention -- clinical precision medicine -- nutrigenomics -- nonpharmacological management -- insulin resistance; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.13070
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : Alzheimer's disease (AD) is a major source of morbidity and mortality, with the disease burden expected to rise as the population ages. No disease‐modifying agent is currently available, but recent research suggests that nutritional and lifestyle modifications can delay or prevent the onset of AD. However, preventive nutritional interventions are not universally applicable and depend on the clinical profile of the individual patient. This article reviews existing nutritional modalities for AD prevention that act through improvement of insulin resistance, correction of dyslipidemia, and reduction of oxidative stress, and discusses how they may be modified on the basis of individual biomarkers, genetics, and behavior. In addition, we report preliminary results of clinical application of these personalized interventions at the first AD prevention clinic in the United States. The use of these personalized interventions represents an important application of precision medicine techniques for the prevention of AD that can be adopted by clinicians across disciplines.