MATS: Global coverage estimates for 4CMenB, a novel multicomponent meningococcal B vaccine. Issue 23 (28th May 2015)

• Record Type: Journal Article
• Authors: Medini, Duccio; Stella, Maria; Wassil, James
• Is Part Of: Vaccine. Volume 33:Issue 23(2015)
• Page Start: 2629
• Page End: 2636
• Publication Date: 2015-05-28
• Subjects: Meningococcal B vaccine -- 4CMenB -- Meningococcal Antigen Typing System -- MATS -- Meningitis; Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.04.015
• Languages: English
• ISSNs: 0264-410X

Abstract

Highlights: MATS is used to identify coverage of MenB strains by 4CMenB. MATS provides an accurate, conservative estimate of 4CMenB strain coverage. 4CMenB strain coverage estimates, 66–91% per country. Global public health implications: predicting the effect of 4CMenB implementation. MATS helps to assess post-vaccine implementation surveillance. Abstract: Recently approved in the EU, US, Australia, and Canada, 4CMenB (Bexsero ®, GSK Vaccines) is a multi-component meningococcal B (MenB) vaccine containing 3 surface exposed recombinant proteins (fHbp, NadA, and NHBA) and New Zealand strain outer membrane vesicles (NZ OMV) containing PorA 1.4. The accepted correlate of protection to assess response to MenB vaccines, the serum bactericidal assay with human complement, is impractical for large panels of strains with diverse antigenic profile and expression. Therefore, the Meningococcal Antigen Typing System (MATS) was developed to identify MenB strains with a high likelihood of being covered by 4CMenB. MATS is used to assess MenB strain coverage without requiring sera, an advantage for testing large panels of bacterial isolates. MATS provides an accurate, conservative estimate of 4CMenB coverage. In a public–private partnership, 10 reference laboratories around the world were established and standardized to facilitate the timely collection and analysis of regional data. MATS has global public health implications for informing local policy makers of the predicted effect of the implementation of the 4CMenB vaccine. Coverage estimates are similar to or better than other recently approved vaccines, ranging from 66% to 91%. The use of MATS in post-vaccine implementation surveillance could provide data regarding vaccine effectiveness in the field and duration of protection on a global scale that will aid in the development of vaccine booster schedules, if necessary. This MATS approach could potentially be applied rapidly to assess epidemiology of other bacterial pathogens and coverage by other protein-based vaccines.